I skilled:
-middle path of enchanting for better armor ( no 2x enchants yet )
-the left side of smithing for light (dragon) armor
-one handed dual wield / power attack / sword stuff
-everything in light armor but only 64 skill
-muffled movement, 6x melee and 3x bow sneak attack in sneak. Not very good points for the endgame I would say. Without overpowered equipment I would probably try out the "crouch makes enemies lose sight of you" thing, but I managed to get by without it for so long...
-Pickpocket for +100 inventory space, I'm such a hoarder, had like 600 inventory space used with hundreds of ingredients and dozens of potions most of the time near the end + husband carrying additional loot. Also unread books.
So I focused pretty much on a few lines.
I use the mouse most of the time for menus and it looks like there is a little bug that makes you select the wrong dialog options. Another bug is ?clicking too far left? in inventory menus closes it instead of selecting the category. I can enchant items pretty fast as long as the list positions don't reset for whatever reason.
Hotkeying stuff is a joke as it doesn't work with dual wielding.