It's a brilliant game, make sure you max speech/science/lockpicking/repair to at least 75 each - they're all quite annoyingly essential to avoid hordes of angry mutants in various parts of the game.
The radio gets really repetitive unfortunately, but it's better than FO3's at least.
Try not to do too much of the main quest too fast, you'll have to choose an allegiance to one of like 5 potential outcomes and your actions there will really dictate how each faction feels about you, and if you don't know them all by then and haven't decided who to side with side quests can become a massive chore
Other than that, explore, do everything! It'll take a few runthroughs to finish it all so i recommend saving often, you might want to go back and do something differently