http://userscripts.org/scripts/show/9620 - Old but some may not know about it
LookItUp2:
Quickly look something up in wikipedia, a dictionary or whatever you like (its easy to add custom sites!). The result is displayed directly on the page.
Very useful, just highlight a word/sentence then press the assigned shortcut, a window will appear in your current window and shows the results for the shortcut you pressed (not replacing your page, just an overlay).
Adding your own custom searches
Adding your own is easy, just use the search function of the site you want to add, search for '[words]' then copy the url from your address bar and use this for the url in the LookItUp2 settings, for example:
http://www.imdb.com/find?s=all&q=[words]&x=0&y=0
So if I highlight a word and press 'm' the imdb search function pops up in an overlay and shows the results to me, then if I have finished looking at it I just click on the original website I was on and it quits the overlay, awesome!